GM Watch
  • Main Menu
    • Home
    • News
      • Newsletter subscription
      • News Reviews
      • News Languages
        • Notícias em Português
        • Nieuws in het Nederlands
        • Nachrichten in Deutsch
      • Archive
    • Articles
      • GM Myth Makers
      • GM Reports
      • GM Quotes
      • GM Myths
      • Non-GM successes
      • GM Firms
        • Monsanto: a history
        • Monsanto: resources
        • Bayer: a history
        • Bayer: resources
    • Videos
      • Latest Videos
      • Must see videos
      • Agriculture videos
      • Labeling videos
      • Animals videos
      • Corporations videos
      • Corporate takeover videos
      • Contamination videos
      • Latin America videos
      • India videos
      • Asia videos
      • Food safety videos
      • Songs videos
      • Protests videos
      • Biofuel myths videos
      • Index of GM crops and foods
      • Index of speakers
      • Health Effects
    • Contact
    • About
    • Donations
News and comment on genetically modified foods and their associated pesticides    
  • News
    • Newsletter subscription
    • News Reviews
    • News Languages
      • Notícias em Português
      • Nieuws in het Nederlands
      • Nachrichten in Deutsch
    • Archive
      • 2022 articles
  • Articles
    • GM Myth Makers
    • GM Reports
    • GM Quotes
    • GM Myths
    • Non-GM successes
    • GM Firms
      • Monsanto: a history
      • Monsanto: resources
      • Bayer: a history
      • Bayer: resources
  • Donations
  • Videos
    • Index of speakers
    • Glyphosate Videos
    • Latest Videos
    • Must see videos
    • Health Effects
    • Agriculture videos
    • Labeling videos
    • Animals videos
    • Corporations videos
    • Corporate takeover videos
    • Contamination videos
    • Latin America videos
    • India videos
    • Asia videos
    • Food safety videos
    • Songs videos
    • Protests videos
    • Biofuel myths videos
    • Index of GM crops and foods
  • Contact
  • About

GMWatch Facebook cornfield banner

INTRODUCTION TO GM

GMO Myths and Facts front page.jpg

SCIENCE SUPPORTS REGULATION OF GENE EDITING

Plant tissue cultures

GENE EDITING: UNEXPECTED OUTCOMES AND RISKS

Damaged DNA on fire

GENE EDITING MYTHS AND REALITY

A guide through the smokescreen

Gene Editing Myths and Reality

ON-TARGET EFFECTS OF GENE EDITING

Damaged DNA

GM crops alter structure and function of liver, new research shows

  • Print
  • Email
Details
Published: 27 May 2004
Twitter

"The article below is a valuable article. It shows eating GM crops alters structure and function of the liver." - Prof Joe Cummins
------

Ultrastructural Morphometrical and Immunocytochemical Analyses of Hepatocyte Nuclei from Mice Fed on Genetically Modified Soybean
Cell Structure and Function
Vol. 27 (2002) , No. 4 pp.173-18

Manuela Malatesta1), Chiara Caporaloni1)2), Stefano Gavaudan2), Marco B.L. Rocchi3), Sonja Serafini4), Cinzia Tiberi1) and Giancarlo Gazzanelli1)

1) Istituto di Istologia e Analisi di Laboratorio, via Zeppi s.n., University of Urbino

2) Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche

3) Istituto di Biomatematica, Località Crocicchia, University of Urbino

4) Istituto di Chimica Biologica "G. Fornaini", via Saffi 2, University of Urbino

ABSTRACT.   No direct evidence that genetically modified (GM) food may represent a possible danger for health has been reported so far; however, the scientific literature in this field is still quite poor. Therefore, we carried out an ultrastructural morphometrical and immunocytochemical study on hepatocytes from mice fed on GM soybean, in order to investigate eventual modifications of nuclear components of these cells involved in multiple metabolic pathways related to food processing. Our observations demonstrate significant modifications of some nuclear features in GM-fed mice. In particular, GM fed-mice show irregularly shaped nuclei, which generally represents an index of high metabolic rate, and a higher number of nuclear pores, suggestive of  intense molecular trafficking. Moreover, the roundish nucleoli of control animals change in more irregular nucleoli with numerous small fibrillar centres and abundant dense fibrillar component in GM-fed mice, modifications typical of increased metabolic rate. Accordingly, nucleoplasmic (snRNPs and SC-35) and nucleolar (fibrillarin) splicing factors are more abundant in hepatocyte nuclei of GM-fed than in control mice. In conclusion, our data suggest that GM soybean intake can influence hepatocyte nuclear features in young and adult mice; however, the mechanisms responsible for such alterations remain unknown.

Menu

Home

Subscriptions

News Archive

News Reviews

Videos

Articles

GM Myth Makers

GM Reports

GM Myths

GM Quotes

Non-GM Successes

Contacts

Contact Us

About

Facebook

Twitter

Donations

Content 1999 - 2023 GMWatch.
Web Development By SCS Web Design