New peer-reviewed paper exposes criticisms of the Séralini study. Claire Robinson reports

Science must be defended against commercial interests that attempt to get important papers on GMOs and pesticides retracted rather than encouraging further research to clarify any uncertainties, says an important new peer-reviewed paper published in Environmental Sciences Europe.

The paper, authored by Drs John Fagan, Terje Traavik and Thomas Bøhn, details the events that followed the publication of the research study led by Prof Gilles-Eric Séralini on GM maize NK603 and Roundup. The Séralini study found toxic effects in rats, notably liver and kidney damage, from NK603 maize and Roundup, both individually and in combination.

The paper was attacked by pro-GMO scientists, who argued that it should be retracted. Eventually the journal editor capitulated and retracted the paper, though it was subsequently republished in Environmental Sciences Europe.

The authors of the new paper comment on this row, lamenting the growth of “a trend in which disputes, between interest groups vying for retraction and republication of papers that report controversial results, overshadow the normal scientific process in which peer-reviewed publication stimulates new research, generating new empirical evidence that drives the evolution of scientific understanding”.

The paper also reviews the research on the safety of NK603 maize and Roundup herbicide for human and livestock health. The authors’ analysis confirms that NK603 maize and Roundup are kidney and liver toxicants at levels below current regulatory thresholds and that “consequently, the regulatory status of NK603, glyphosate and Roundup requires reevaluation”.

The authors also say that preliminary evidence from the Séralini study indicates that Roundup and NK603, individually and in combination, may increase tumour incidence and mortality. They conclude, “Follow-up long-term carcinogenicity studies, using test animal strains and numbers of animals that assure robust conclusions, are required to confirm/refute this preliminary evidence.”

The paper represents a comprehensive summary of the gaping holes in the pro-GMO lobby’s critiques of the Séralini study. Sadly, the European Food Safety Authority (EFSA) must consider itself part of this lobby. This is because EFSA followed the pro-GMO lobby in portraying the Séralini study as a failed carcinogenicity study, rather than what it really was – a chronic toxicity study that unexpectedly found increased tumour and mortality incidence in treated rats and which must therefore be followed up with a dedicated carcinogenicity study using larger numbers of animals.

Thus EFSA effectively pretended not to notice the main findings of the Séralini study: that NK603 GM maize and Roundup caused an increase in liver and kidney damage. The new paper sets the record straight and gives the Séralini study its due status as evidence of these serious toxic effects. It also recommends reforms in the regulatory process that would help protect due scientific process from interference by commercial interests.
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The Seralini affair: degeneration of Science to Re‑Science?

John Fagan, Terje Traavik and Thomas Bøhn
Environ Sci Eur (2015) 27:19
http://www.enveurope.com/content/27/1/19 (open access)

Abstract
A paper reporting findings relevant to safety of the genetically modified (GM) maize NK603 and the herbicide Roundup (Séralini et al., Food Chem Toxicol. 50:4221–4231, 2012) was retracted against the wishes of the authors, and subsequently republished in another peer-reviewed journal (Séralini et al. Environ Sci Europe, doi:10.1186/s12302-014-0014-5, 2014). These events exemplify a trend in which disputes, between interest groups vying for retraction and republication of papers that report controversial results, overshadow the normal scientific process in which peer-reviewed publication stimulates new research, generating new empirical evidence that drives the evolution of scientific understanding. This paper reviews the current status of research on safety of NK603 maize and Roundup herbicide for human and livestock health, and attempts to glean from recent developments insights relevant to risk assessment policy for GM crops and pesticides, as well as relevant to the scientific process in general. Our analysis of currently published evidence confirms NK603 and Roundup are kidney and liver toxicants at levels below current regulatory thresholds. Consequently, the regulatory status of NK603, glyphosate and Roundup requires reevaluation. Additionally, preliminary evidence indicates Roundup and NK603, individually and in combination, may increase tumor incidence and mortality. Follow-up long-term carcinogenicity studies, using test animal strains and numbers of animals that assure robust conclusions, are required to confirm/refute this preliminary evidence. The inherent tension between the scientific process and commercial interests of product developers necessitates implementation of safeguards that protect the scientific process and prevent degeneration of Science to Re-Science (typified by retraction and republication disputes).